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KMID : 1161420130160100957
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Journal of Medicinal Food
2013 Volume.16 No. 10 p.957 ~ p.960
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The I148M Variant of PNPLA3 Reduces the Response to Docosahexaenoic Acid in Children with Non-Alcoholic Fatty Liver Disease
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Nobili Valerio
Bedogni Giorgio
Donati Benedetta
Alisi Anna
Valenti Luca
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Abstract
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The aim of this secondary analysis of a randomized controlled trial was to test whether the I148M variant of Patatin-like phospholipase domain-containing protein-3 (PNPLA3) is associated with the response to docosahexaenoic acid (DHA) in children with non-alcoholic fatty liver disease (NAFLD). Sixty children with NAFLD were randomized in equal numbers to DHA 250?mg/day, DHA 500?mg/day or placebo. Coherently with the primary analysis, the probability of more severe steatosis after 24 months of DHA supplementation was 50% lower [95% confidence interval (CI) ?59% to ?42%)] in the combined DHA 250 and 500?mg/day groups versus placebo. The present secondary analysis revealed an independent effect of PNPLA3 status on the response to DHA. In fact, the probability of more severe steatosis was higher (37%, 95% CI 26?48%) for the PNPLA3?M/M versus I/M genotype and lower (?12%, 95% CI ?21% to ?3%) for the I/I versus I/M genotype (Somers' D for repeated measures). We conclude that the 148M allele of PNPLA3 is associated with lower response, and the 148I allele with greater response, to DHA supplementation in children with NAFLD.
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KEYWORD
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children, docosahexaenoic acid, non-alcoholic fatty liver disease, randomized controlled trial
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